Chymotrypsin 100k au is an oral medicine belonging to the category of proteolytic enzymes and is used to treat  

1. Pain and swelling after surgeries 
2. Improves wound healing after surgeries and injuries        

More Common  

1. Nausea   
2. Vomiting  
3. Diarrhea  
4. Headache  
5. Dizziness  
6. Rash  
7. Itching  
8. Fatigue           

Less Common 

1. Allergy  
2. Arrhythmia 
3. Breathing difficulty 
4. Liver‑stress 
5. Chest pain 
6. Swelling (face/lips) 
7. Jaundice         

Chymotrypsin works by breaking down unwanted proteins at the site of injury or swelling. This clears out damaged tissue and reduces the buildup that causes pain and inflammation. As a result, blood flows better and healing becomes faster and smoother.

Allergy or Hypersensitivity

If you have ever had a rash, itching, swelling, breathing problem, or severe allergic reaction after taking any medicines, communicate with your doctor before taking this medicine. 

Pregnancy

Chymotrypsin should not be used in pregnancy because there is not enough safety information, and it may increase the risk of bleeding or allergic reactions. Always consult a doctor before using it. 

Breastfeeding

Chymotrypsin is not advised during breastfeeding because there is very little safety data, and it may pass into breast milk or cause stomach upset and allergy in the baby. Always consult a doctor before using it.

Liver problems

If you have liver disease, talk to your doctor before taking this medicine because both medicines are processed in the liver and may need caution. Severe liver disease has limited data. 

Kidney problems

If you have severe kidney problems, ask your doctor before using this medicine. Dose adjustment is usually not needed in mild-moderate cases, but severe cases should be monitored.

Chymotrypsin is generally safe with food, and it is recommended to avoid alcohol and smoking with chymotrypsin, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain. 

Avoid taking Chymotrypsin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Chymotrypsin: α‑Chymotrypsin  

Daily dose

Take Chymotrypsin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

 It is not recommended to take more than 300 mg of Chymotrypsin per day, as it may cause severe adverse effects like extreme drowsiness, confusion, low blood pressure, unconsciousness, high fever, severe diarrhea, and heart weakness. 

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children. 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

Chymotrypsin 100,000 AU is a proteolytic enzyme drug used mainly to reduce swelling, pain, and inflammation after surgery or injury. It is F approved for postoperative recovery and trauma care, and off label uses include arthritis, soft tissue healing, and circulation improvement. Its mechanism of action is breaking down harmful proteins at the injury site to clear damaged tissue and improve blood flow. Common side effects include nausea, diarrhea, headache, dizziness, rash, and itching, while rare ones are allergy, breathing difficulty, or irregular heartbeat.

It can interact with food and alcohol, sometimes causing worsening stomach upset. People with bleeding disorders, severe allergies, or liver disease, or pregnant women should avoid it. Taking more than 300 mg per day may cause severe stomach upset, bleeding risk, allergic reactions, or heart rhythm problems, requiring urgent medical care. 

What is the mechanism of action of chymotrypsin? 

Chymotrypsin works by cutting and breaking down proteins at the site of injury or swelling. This clears damaged tissue, reduces inflammation, and improves blood flow, which helps the body heal faster.

What are the uses of chymotrypsin tablets? 

Chymotrypsin tablets are mainly used to reduce pain, swelling, and inflammation after surgery, injury, or trauma, and they help wounds heal faster by improving blood circulation. 

What are the side effects of chymotrypsin 100k au tablets? 

Chymotrypsin 100k AU tablets are generally well tolerated, but they can sometimes cause mild stomach upset, nausea, diarrhea, headache, dizziness, or skin rash, and rarely may trigger allergic reactions like itching, swelling, or breathing difficulty.

1. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for Chymotrypsin; [cited 2026 Mar. 12]. Available from. 
2. Practo. Trypsin + Chymotrypsin. Practo [Internet]. [cited 2026 Mar 12]. Available from. 
3. WebMD. Chymotrypsin – Uses, Side Effects, and More [Internet]. WebMD; [cited 2026 Mar 12]. Available from. 
4. ScienceDirect. Chymotrypsin [Internet]. Elsevier; [cited 2026 Mar 12]. Available from.