Magaldrate 400 mg + Simethicone 200 mg/5 ml syrup is a combination of Magaldrate 400mg + Simethicone 20mg/5ml. Magaldrate 400mg + Simethicone 20mg/5ml is used to relieve acidity, heartburn, indigestion and stomach discomfort caused by excess acid. Magaldrate belongs to the antacid class and works by neutralizing extra acid in the stomach, while Simethicone belongs to the antiflatulent class and works by breaking gas bubbles so the gas can pass out more easily. This helps reduce burning in the stomach, heaviness, fullness, and bloating, giving quick relief from digestive discomfort.  

It is usually taken after food or as advised by the doctor. Common side effects of Magaldrate 400mg + Simethicone 20mg/5ml include constipation, diarrhea, nausea, chalky taste, and mild stomach discomfort. It should be used carefully in people with kidney problems and should only be taken as prescribed by the doctor.

Magaldrate 400mg + Simethicone 20mg/5ml syrup is an oral antacid + antiflatulent medicine. Magaldrate 400mg + Simethicone 20mg/5ml is used to treat the following conditions:

1. Acidity and heartburn 
2. Indigestion 
3. Stomach discomfort due to excess acid 
4. Supportive relief in stomach ulcers   

1. Take Magaldrate 400mg + Simethicone 20mg/5ml exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Magaldrate 400mg + Simethicone 20mg/5ml without your doctor’s approval, even if you feel better. 
3. If you forget to take Magaldrate 400mg + Simethicone 20mg/5ml, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

More Common  

1. Chalky taste 
2. Constipation 
3. Diarrhea 
4. Nausea 
5. Stomach discomfort  

Less Common 

1. Allergic reaction (rash, swelling, breathing trouble) 
2. Weakness 
3. Confusion (rare, with long-term overuse) 
4. Bone pain or muscle weakness (rare, with long-term use) 
5. Kidney-related toxicity in susceptible people   

Magaldrate works by reducing extra acid in the stomach, which helps relieve acidity, heartburn, and indigestion. Simethicone works by breaking small gas bubbles into bigger ones, so the gas can pass out more easily. This helps reduce bloating, fullness, and stomach discomfort.  

Allergic Reactions

Magaldrate 400mg + Simethicone 20mg/5ml may cause rash, itching, swelling, or breathing trouble in people allergic to it. Always inform your doctor if you have any allergies before taking Magaldrate 400mg + Simethicone 20mg/5ml.

Liver Disease Monitoring

People with liver problems may need extra caution while using Magaldrate 400mg + Simethicone 20mg/5ml. Always inform your doctor if you have any liver disease before taking Magaldrate 400mg + Simethicone 20mg/5ml.

Kidney problems

Magaldrate 400mg + Simethicone 20mg/5ml may build up the body and increase the risk of side effects like weakness, confusion, or mineral imbalance in people with kidney problems. Always inform your doctor if you have any kidney disease before taking Magaldrate 400mg + Simethicone 20mg/5ml.

Bowel blockage

Magaldrate 400mg + Simethicone 20mg/5ml may worsen stomach pain, vomiting, or blockage symptoms in people with intestinal obstruction. Always inform your doctor if you have any bowel blockage or severe constipation before taking Magaldrate 400mg + Simethicone 20mg/5ml.

Pregnancy

If you are pregnant, consult your doctor before taking Magaldrate 400mg + Simethicone 20mg/5ml because it may affect the baby, especially in the later months of pregnancy.

Breastfeeding

If you are breastfeeding, consult your doctor before taking Magaldrate 400mg + Simethicone 20mg/5ml because small amounts may pass into breast milk and may affect the baby.

Magaldrate 400mg + Simethicone 20mg/5ml is usually taken after food because it helps give better relief from acidity, heartburn, and gas. Avoid very spicy, oily, fried, or heavy meals, as they can increase stomach acid and make your symptoms worse. It is also better to avoid alcohol, smoking, too much tea, and coffee, as they may irritate the stomach and increase acidity.             

Avoid taking Magaldrate 400mg + Simethicone 20mg/5ml with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry) Name

Magaldrate: pentaaluminum;decamagnesium;hentriacontahydroxide;disulfate;hydrate  

Simethicone: dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane 

Daily dose

Take Magaldrate 400mg + Simethicone 20mg/5ml exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

It is not recommended to take Magaldrate 400mg + Simethicone 20mg/5ml more than 500 mg per day. Overdose may cause tremors, chest pain, fast or irregular heartbeat, nervousness, dizziness, headache, muscle cramps, or high blood pressure. In case of any of these symptoms, seek immediate medical help.

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

What are the uses of magaldrate syrup? 

Magaldrate syrup is used to relieve acidity, heartburn, indigestion, sour stomach, and stomach discomfort caused by excess acid. It may also help in gastritis and give supportive relief in stomach ulcers. 

What are the side effects of Magaldrate? 

Common side effects of Magaldrate include constipation, diarrhea, mild stomach discomfort, bad/chalky taste, and loss of appetite. In rare cases, long-term or excessive use may cause muscle weakness, bone pain, or mineral imbalance, especially in people with kidney problems. 

What drug class does Magaldrate belong to? 

Magaldrate belongs to the antacid drug class. It works by neutralizing excess stomach acid and helps relieve acidity and heartburn. 

What are the uses of Simethicone? 

Simethicone is used to relieve gas, bloating, stomach fullness, and pressure caused by excess gas in the stomach and intestines. It is commonly used in babies, children, and adults for gas discomfort. 

What are the side effects of Simethicone? 

Simethicone usually has very few or no common side effects. Rarely, some people may have constipation, nausea, rash, itching, swelling, or allergic reactions. 

1. Magaldrate / Simethicone Dosage Guide + Max Dose, Adjustments [Internet]. Drugs.com. Drugs.com; 2024. Available from 
2. PubChem. Simethicone [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
3. PubChem. Magaldrate [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Apr 4]. Available from 
4. Magaldrate: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Drugbank.com. DrugBank; 2020. Available from 
5. Simethicone [Internet]. go.drugbank.com. Available from 
6. Mayo Clinic. Simethicone (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. Mayoclinic.org. 2019. Available from