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Diclofenac 50 mg + Metaxalone 400 mg tablet is used to relieve pain, inflammation, muscle stiffness, and muscle spasms associated with conditions such as acute musculoskeletal pain, low back pain, neck pain, sprains, strains, sports injuries, and other painful muscle disorders. This medicine consists of active ingredients such as diclofenac and metaxalone, where diclofenac works by blocking the production of certain chemicals (prostaglandins) that cause pain and inflammation, while metaxalone acts as a muscle relaxant by reducing muscle spasms through its action on the central nervous system, helping improve movement and reduce discomfort.
The dose should be taken exactly as prescribed by a doctor. Do not take more than the recommended dose or use it for longer than advised.
Common side effects include drowsiness, dizziness, nausea, vomiting, stomach pain, indigestion, headache, and dry mouth. In rare cases, it may cause stomach ulcers, gastrointestinal bleeding, severe allergic reactions, liver problems, kidney problems, or severe drowsiness that require immediate medical attention.
| Uses | 1. To treat acute musculoskeletal pain 2. To relieve muscle spasms 3. To treat low back and neck pain 4. To relieve pain due to sprains and strains 5. To reduce pain and inflammation associated with sports injuries |
| Common Side Effects | 1. Drowsiness 2. Dizziness 3. Dry mouth 4. Stomach pain 5. Nausea 6. Indigestion 7. Weakness 8. Headache |
| Additional Information | To keep you safe and healthy, use this medicine only with your doctor’s guidance. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medication orally with a sip of water. |
Diclofenac 50 mg + Metaxalone 400 mg is used to treat following infections:
This medicine consists of active ingredients such as diclofenac 50 mg and metaxalone 400 mg that work together to relieve pain and muscle spasms. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain, swelling, and inflammation by blocking the production of prostaglandins (pain-producing chemicals in the body). Metaxalone is a centrally acting muscle relaxant that helps reduce muscle spasm and stiffness, allowing muscles to relax and improve mobility.
If you are allergic to diclofenac, metaxalone, other NSAIDs, or any of the ingredients in this medicine, avoid using it. Serious allergic reactions such as rash, itching, swelling, or difficulty breathing may occur.
If you have a history of stomach ulcers, gastrointestinal bleeding, or inflammatory bowel disease, diclofenac may worsen these conditions. Always inform your doctor about your medical history before starting treatment.
Patients with liver or kidney problems may require dose adjustments. Consult your doctor before taking this medicine.
Metaxalone may cause drowsiness, dizziness, or reduced alertness. Avoid driving, operating machinery, or performing activities that require concentration until you know how the medicine affects you.
Avoid excessive alcohol consumption while taking this medicine, as it may increase the risk of stomach irritation, excessive drowsiness, dizziness, and liver damage.
Avoid taking Diclofenac 50 mg + Metaxalone 400 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Diclofenac: 2-[2-(2,6-dichloroanilino) phenyl] acetic acid

Metaxalone: 5-[(3,5-dimethylphenoxy) methyl]-1,3-oxazolidin-2-one

Take Diclofenac 50 mg + Metaxalone 400 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
It is not recommended to take more than the prescribed dose of Diclofenac 50 mg + Metaxalone 400 mg. Overdose may cause severe stomach pain, nausea, vomiting, dizziness, drowsiness, stomach bleeding, kidney problems, or liver damage. Seek immediate medical attention if overdose symptoms occur.
Metaxalone 400 mg + Diclofenac 50 mg tablets are used to relieve pain, inflammation, muscle stiffness, and muscle spasms associated with conditions such as low back pain, neck pain, sprains, strains, sports injuries, and other musculoskeletal disorders.
Yes. This combination is commonly prescribed for muscle spasm. Metaxalone relaxes the muscles, while diclofenac reduces pain and inflammation, providing effective relief from painful muscle conditions.
It is generally recommended to take Metaxalone 400 mg + Diclofenac 50 mg tablets after food or as advised by your doctor. Taking medicine with food may help reduce stomach irritation caused by diclofenac.
Take Metaxalone 400 mg + Diclofenac 50 mg tablets only for the duration and dose prescribed by your doctor. Long-term or excessive use without medical supervision may increase the risk of stomach ulcers, liver problems, kidney problems, or other serious side effects.


Reviewed By-
Mahak PhartyalMedical Content writer and reviewer
Bachelors in Pharmacy | 3+ Year experience
Last Updated: 18 Jul 2026
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