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Diclofenac 50 mg + Metaxalone 400 mg | Tablet

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Diclofenac 50 mg + Metaxalone 400 mg | Tablet

Rx Required

Drug Code: 1596

Rx Required
| tablettablet| Pack of 10 tablets
MRP ₹195

₹56

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Batch Details

Composition

diclofenac 50 mg + metaxalone 400 mg

Batch

44|CBT26-0250

Expiry

January 2028

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Batch Details

Composition

diclofenac 50 mg + metaxalone 400 mg

Batch

44|CBT26-0250

Expiry

January 2028

About Diclofenac 50 mg + Metaxalone 400 mg

Diclofenac 50 mg + Metaxalone 400 mg tablet is used to relieve pain, inflammation, muscle stiffness, and muscle spasms associated with conditions such as acute musculoskeletal pain, low back pain, neck pain, sprains, strains, sports injuries, and other painful muscle disorders. This medicine consists of active ingredients such as diclofenac and metaxalone, where diclofenac works by blocking the production of certain chemicals (prostaglandins) that cause pain and inflammation, while metaxalone acts as a muscle relaxant by reducing muscle spasms through its action on the central nervous system, helping improve movement and reduce discomfort. 

The dose should be taken exactly as prescribed by a doctor. Do not take more than the recommended dose or use it for longer than advised. 

Common side effects include drowsiness, dizziness, nausea, vomiting, stomach pain, indigestion, headache, and dry mouth. In rare cases, it may cause stomach ulcers, gastrointestinal bleeding, severe allergic reactions, liver problems, kidney problems, or severe drowsiness that require immediate medical attention.    

Medicine Highlights

Uses 1. To treat acute musculoskeletal pain  
2. To relieve muscle spasms  
3. To treat low back and neck pain  
4. To relieve pain due to sprains and strains 
5. To reduce pain and inflammation associated with sports injuries    
Common Side Effects  1. Drowsiness  
2. Dizziness  
3. Dry mouth  
4. Stomach pain  
5. Nausea  
6. Indigestion  
7. Weakness  
8. Headache 
Additional Information To keep you safe and healthy, use this medicine only with your doctor’s guidance. 
Storage 1. The medicine should be stored at room temperature.  
2. Keep away from sunlight and moisture.  
3. Keep away from the reach of children 
How to Take This MedicineTake this medication orally with a sip of water.

Diclofenac 50 mg + Metaxalone 400 mg Uses

Diclofenac 50 mg + Metaxalone 400 mg is used to treat following infections:

  1. Acute musculoskeletal pain  
  2. Muscle spasms  
  3. Low back pain  
  4. Neck pain  
  5. Sprains and strains  
  6. Sports injuries and painful muscle conditions                       

Diclofenac 50 mg + Metaxalone 400 mg side effects

More Common

  1. Drowsiness  
  2. Dizziness  
  3. Nausea  
  4. Vomiting  
  5. Stomach pain  
  6. Indigestion  
  7. Headache  
  8. Dry mouth                

Less Common 

  1. Stomach ulcer  
  2. Gastrointestinal bleeding  
  3. Liver function abnormalities  
  4. Kidney problems  
  5. Severe allergic reactions  
  6. Skin rash  
  7. Swelling of the face or throat  
  8. Yellowing of the skin or eyes (jaundice)            

How Diclofenac 50 mg + Metaxalone 400 mg work

This medicine consists of active ingredients such as diclofenac 50 mg and metaxalone 400 mg that work together to relieve pain and muscle spasms. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain, swelling, and inflammation by blocking the production of prostaglandins (pain-producing chemicals in the body). Metaxalone is a centrally acting muscle relaxant that helps reduce muscle spasm and stiffness, allowing muscles to relax and improve mobility. 

Safety Measures and Warning

Allergy/Hypersentivity

If you are allergic to diclofenac, metaxalone, other NSAIDs, or any of the ingredients in this medicine, avoid using it. Serious allergic reactions such as rash, itching, swelling, or difficulty breathing may occur.

Stomach Disorders

If you have a history of stomach ulcers, gastrointestinal bleeding, or inflammatory bowel disease, diclofenac may worsen these conditions. Always inform your doctor about your medical history before starting treatment.

Liver or kidney disease

Patients with liver or kidney problems may require dose adjustments. Consult your doctor before taking this medicine.

Drowsiness

Metaxalone may cause drowsiness, dizziness, or reduced alertness. Avoid driving, operating machinery, or performing activities that require concentration until you know how the medicine affects you.

Diclofenac 50 mg + Metaxalone 400 mg Interaction with Food Product

Avoid excessive alcohol consumption while taking this medicine, as it may increase the risk of stomach irritation, excessive drowsiness, dizziness, and liver damage.

Diclofenac 50 mg + Metaxalone 400 mg Interaction with Other Medicines

Avoid taking Diclofenac 50 mg + Metaxalone 400 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Diclofenac 50 mg + Metaxalone 400 mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Diclofenac: 2-[2-(2,6-dichloroanilino) phenyl] acetic acid 

Diclofenac 50 mg 

Metaxalone: 5-[(3,5-dimethylphenoxy) methyl]-1,3-oxazolidin-2-one 

Metaxalone 400 mg

Intake routine/cycle

Daily dose

Take Diclofenac 50 mg + Metaxalone 400 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than the prescribed dose of Diclofenac 50 mg + Metaxalone 400 mg. Overdose may cause severe stomach pain, nausea, vomiting, dizziness, drowsiness, stomach bleeding, kidney problems, or liver damage. Seek immediate medical attention if overdose symptoms occur.

Storage

  1. Store the medicine at room temperature. 
  2. Keep away from sunlight and moisture. 
  3. Keep out of reach of children 

Directions for use

  1. Take Diclofenac 50 mg + Metaxalone 400 mg exactly as prescribed by your doctor, at the same time each day. 
  2. Do not stop taking Diclofenac 50 mg + Metaxalone 400 mg without your doctor’s approval, even if you feel better. 
  3. If you forget to take Diclofenac 50 mg + Metaxalone 400 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

FAQ’s

What are the uses of Metaxalone 400 mg + Diclofenac 50 mg tablets? 

Metaxalone 400 mg + Diclofenac 50 mg tablets are used to relieve pain, inflammation, muscle stiffness, and muscle spasms associated with conditions such as low back pain, neck pain, sprains, strains, sports injuries, and other musculoskeletal disorders.

Can Metaxalone 400 mg + Diclofenac 50 mg tablets be taken for muscle spasms? 

Yes. This combination is commonly prescribed for muscle spasm. Metaxalone relaxes the muscles, while diclofenac reduces pain and inflammation, providing effective relief from painful muscle conditions.

Should Metaxalone 400 mg + Diclofenac 50 mg tablets be taken before or after food? 

It is generally recommended to take Metaxalone 400 mg + Diclofenac 50 mg tablets after food or as advised by your doctor. Taking medicine with food may help reduce stomach irritation caused by diclofenac. 

Can I take Metaxalone 400 mg + Diclofenac 50 mg tablets every day? 

Take Metaxalone 400 mg + Diclofenac 50 mg tablets only for the duration and dose prescribed by your doctor. Long-term or excessive use without medical supervision may increase the risk of stomach ulcers, liver problems, kidney problems, or other serious side effects.

Reference

  1. PubChem. PubChem [Internet]. Nih.gov. PubChem; 2026 [cited 2026 July 6]. Available from 
  2. Metaxalone (oral route) [Internet]. Mayo Clinic. 2025. Available from 
  3. Diclofenac (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. Available from 
  4. Alfaro RA, Modi PV. Diclofenac [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023. Available from 
  5. Metaxalone tablets [Internet]. Cleveland Clinic. Available from              
Pranathi Chintaluri avatar

Written By-

Pranathi Chintaluri

Medical content writer

Doctor of Pharmacy | 2+ Year experience

Mahak Phartyal avatar

Reviewed By-

Mahak Phartyal

Medical Content writer and reviewer

Bachelors in Pharmacy | 3+ Year experience

Last Updated: 18 Jul 2026

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