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Liquid paraffin 1.25 ml + milk of magnesia 3.75 ml + sodium picosulphate 3.33 mg/5 ml is an oral laxative suspension. Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml is used to treat constipation. It combines three agents that work together to soften the stool, draw water into the intestines, and stimulate bowel movements. This combination provides gentle and effective relief from constipation, especially in elderly patients, or those recovering from surgery. It is usually taken at bedtime with plenty of water and should not be used for more than a few days without medical advice. Common side effects of Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml are abdominal cramps, diarrhea, and bloating.
| Uses | 1. To relieve symptoms of constipation 2. To relieve symptoms of straining during bowel movements |
| Common Side Effects | 1. Diarrhoea 2. Abdominal discomfort 3. Pain or cramps 4. Loss of appetite 5. Dizziness 6. Fatigue 7. Itching of skin 8. 9. Muscle weakness Vomiting |
| Additional Information | 1. Avoid taking alcohol or tobacco with this medicine. 2. Not for long-term use; may cause dependency if used regularly. 3. Use with caution in children and the elderly. 4. Drink plenty of fluids while using this medicine. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | To be taken orally |
Liquid paraffin 1.25 ml+ milk of magnesia 3.75ml+ sodium picosulphate 3.33mg/ 5ml is oral medicines belonging to the class of laxatives. Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml is used to treat following indications:
Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml works together to relieve constipation through a combined action. Liquid paraffin acts as a lubricant, coating the stool and intestinal lining to ease its passage. Milk of magnesia is an osmotic laxative that draws water into the intestines, softening the stool and making it easier to pass. Sodium picosulphate is a stimulant laxative that activates the nerves in the colon, increasing bowel movements by enhancing muscle contractions. This triple-action formula helps in effective and gentle relief from constipation.
If you have previously had an allergy to this medicine, inform your doctor.
Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml is generally not recommended during pregnancy unless clearly advised by a doctor, as stimulant laxatives may trigger labor pains. Aceclofenac may also pose risks during pregnancy. Do not take this medicine if you are pregnant, planning to conceive, or breastfeeding.
Long-term use or overdose may lead to loss of important electrolytes (like sodium and potassium), causing weakness or dehydration. Hence this medication should use with caution. Tell your doctor before treatment.
Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml can draw excess water into the intestines. Drink plenty of fluids to prevent dehydration, especially in elderly patients.
Avoid use if you have symptoms of intestinal blockage (severe abdominal pain, vomiting, or bloating) always consult your doctor in such cases
Avoid taking Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Avoid high-fat meals and dairy products while taking this medicine, as they may increase bloating or worsen abdominal discomfort. Take it on an empty stomach or at bedtime for best results. Drink plenty of water and avoid alcohol or caffeine to prevent dehydration.
Liquid paraffin: dodecane (C₁₂H₂₆) or tetradecane (C₁₄H₃₀)

Milk of magnesia: magnesium;dihydroxide

Sodium picosulphate – 4,4′-(2-pyridylmethylene)diphenyl bis(hydrogen sulfate) disodium salt

Take Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Don’t take liquid paraffin+milk of magnesia+sodium picosulfate more than 5 to 15 ml as it may cause severe diarrhea, dehydration, abdominal cramps, and electrolyte imbalance. In case of overdose, seek immediate medical help.
The usual adult dose is 5 to 15 ml once daily at bedtime, while for children, the dose is usually 2.5 to 5 ml, as directed by the doctor. Always measure with the cup provided and follow medical advice.
Liquid paraffin 1.25 ml+ Milk of Magnesia 3.75ml+ Sodium Picosulphate 3.33mg/ 5ml is used to relieve constipation, soften stools, ease bowel movements, and prepare the bowel before surgery or diagnostic procedures.
Sodium picosulfate is used to treat constipation and to clear the bowel before surgeries or diagnostic procedures like colonoscopy.


Reviewed By-
Mahak PhartyalMedical Content writer and reviewer
Bachelors in Pharmacy | 3+ Year experience
Last Updated: 05 May 2026
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