Paracetamol 250 mg and Caffeine 25 mg is a combination medicine used to relieve mild to moderate pain and fever. It is commonly used for headaches, migraines, toothache, body aches, menstrual pain, muscle pain, joint pain, and fever associated with infections. 

Paracetamol works by reducing pain and fever, while Caffeine enhances the pain-relieving effect of Paracetamol and helps improve alertness and reduce fatigue. Common side effects include nausea, stomach discomfort, nervousness, restlessness, dizziness, and difficulty sleeping. 

Rare but serious side effects may include severe allergic reactions, liver damage (especially with overdose), and severe skin reactions. Overall, this medicine helps provide effective relief from pain and fever while improving the effectiveness of pain management.

Paracetamol 250 mg and Caffeine 25 mg is used to treat the following conditions:

1. Headache and migraine pain  
2. Fever  
3. Muscle, joint and other body pains 
4. Menstrual pain and cramps    

More Common

1. Nausea  
2. Stomach discomfort  
3. Dizziness  
4. Nervousness  
5. Restlessness  
6. Difficulty sleeping  
7. Increased heart rate  
8. Mild tremors       

Less Common 

1. Severe allergic reactions (rash, swelling, breathing difficulty)  
2. Liver problems (yellow skin or eyes, dark urine)  
3. Severe skin reactions  
4. Fast or irregular heartbeat  
5. Severe anxiety or agitation  

This combination works by relieving pain and reducing fever through two different mechanisms. Paracetamol acts on the brain’s pain and temperature-regulating centers to reduce pain and fever. Caffeine stimulates the central nervous system and enhances the pain-relieving effects of Paracetamol, making it more effective in managing headaches and other painful conditions. Together, they provide faster and more effective pain relief.

Allergy/Hypersentivity

If you are allergic to Paracetamol, Caffeine, or any ingredient in this medicine, avoid using it as it may cause serious allergic reactions.

Liver Problems

Patients with liver disease should use this medicine cautiously because Paracetamol is processed by the liver and may worsen liver function if taken in high doses.

Kidney Problems

Use caution in people with severe kidney disease and follow your doctor’s advice.

Heart Conditions

People with heart disease, irregular heartbeat, or uncontrolled high blood pressure should consult their doctor before taking this medicine because caffeine may increase heart rate.

Pregnancy and Breastfeeding

Use Paracetamol 250 mg and Caffeine 25 mg during pregnancy or breastfeeding only if recommended by your doctor.

Avoid excessive intake of coffee, tea, energy drinks, or other caffeinated beverages while taking this medicine, as it may increase nervousness, restlessness, and difficulty sleeping.

Avoid taking Paracetamol 250 mg and Caffeine 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Paracetamol: N-(4-hydroxyphenyl) acetamide 

Caffeine: 1,3,7-trimethylpurine-2,6-dione 

Daily dose

Take Paracetamol 250 mg and Caffeine 25 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than the prescribed dose of Paracetamol 250 mg + Caffeine 25 mg, as overdose may cause severe nausea, vomiting, stomach pain, excessive sweating, restlessness, rapid heartbeat, liver damage, or serious health complications. Seek immediate medical attention if overdose symptoms occur.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take Paracetamol 250 mg and Caffeine 25 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Paracetamol 250 mg and Caffeine 25 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Paracetamol 250 mg and Caffeine 25 mg, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

What are the side effects of Paracetamol? 

Paracetamol may cause nausea, upset stomach, or mild rash and itching. Rarely, it can lead to severe allergic reactions like swelling, difficulty breathing, or hives, and liver damage if taken in high doses or for a long time. Always follow the recommended dose and consult a doctor if serious symptoms occur. 

How does Paracetamol work? 

Paracetamol reduces pain and fever by acting on the brain to lower body temperature and block pain signals. 

What is the recommended Paracetamol dosage per day? 

For adults, the usual dose is 500–1000 mg every 4–6 hours, not exceeding 4 grams (4000 mg) in 24 hours. Always follow your doctor’s advice and avoid taking multiple medicines containing Paracetamol at the same time. 

What is caffeine? 

Caffeine is a natural stimulant found in coffee, tea, cocoa, energy drinks, and some medicines. It works by stimulating the brain and central nervous system, helping you feel more awake, alert, and less tired. 

What are the benefits of caffeine? 

Caffeine can help improve alertness, concentration, and mental focus. It may reduce tiredness, enhance physical performance, and improve the effectiveness of certain pain-relieving medicines, especially those used for headaches and migraines. 

What are the side effects of caffeine? 

Common side effects of caffeine include nervousness, restlessness, difficulty sleeping, increased heart rate, shakiness, headache, and stomach discomfort. Taking too much caffeine may cause anxiety, palpitations, or dizziness in some people. 

1. PubChem. Caffeine [Internet]. pubchem.ncbi.nlm.nih.gov. 2023. Available from 
2. Evans J, Battisti AS, Richards JR. Caffeine [Internet]. National Library of Medicine. StatPearls Publishing; 2024. Available from 
3. Lanteri-Minet M, Pegahi R. Paracetamol and Caffeine Combination in Pain Management: A Narrative Review. Valeriani M, editor. Pain Research and Management. 2025 Jan;2025(1) 
4. NHS. Paracetamol for Adults [Internet]. NHS. NHS; 2019. Available from 
5. Ayoub SS. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action. Temperature [Internet]. 2021 Mar 16;8(4):351–71. Available from