Tolperisone 150 mg + Acetaminophen 325 mg tablets ais used to relieve muscle and joint pain, muscle spasms, stiffness, and post-surgical pain. Tolperisone gives muscle relaxation by acting on brain and spinal cord, while Acetaminophen helps reduce pain and fever. 

Common side effects of Tolperisone 150 mg + Acetaminophen 325 mg tablet includes dizziness, nausea, weakness, stomach discomfort, headache, or drowsiness. Rare but serious side effects may include allergic reactions or liver problems if taken in excess. This tablet should be taken exactly as prescribed by the doctor, preferably after food.        

Tolperisone 150 mg + Acetaminophen 325 mg tablets is used to treat the following conditions:

1. Muscle spasms 
2. Back pain 
3. Neck pain 
4. Muscle stiffness 
5. Musculoskeletal pain 
6. Muscle injury pain 
7. Joint pain  
8. Post surgical pain              

More Common

1. Dizziness 
2. Nausea 
3. Weakness 
4. Headache 
5. Drowsiness 
6. Stomach discomfort           

Less Common 

1. Allergic reactions 
2. Skin rash 
3. Liver problems 
4. Breathing difficulty          

Tolperisone 150 mg + Acetaminophen 325 mg tablet consists of tolperisone and acetaminophen. Tolperisone acts on brain and spinal cord, resulting in muscle relaxation, whereas acetaminophen reduces the action of pain enzymes (cyclooxygenase), resulting in relief from pain.

Allergy / Hypersensitivity

 Tolperisone 150 mg + Acetaminophen 325 mg tablet may cause allergic reactions such as rash, itching, swelling, or breathing difficulty. Stop taking the medicine and consult your doctor if symptoms worsen.

Liver Problems

Acetaminophen should be used carefully in patients with liver disease or alcohol use, as high doses may damage the liver. Communicate with your doctor about your past disease history.

Pregnancy

If you are pregnant or planning to become pregnant, inform your doctor before taking Tolperisone 150 mg + Acetaminophen 325 mg tablet because its safety during pregnancy has not been fully established. 

Breastfeeding

If you are breastfeeding, inform your doctor before using this medicine because it is not clearly known whether Tolperisone 150 mg + Acetaminophen 325 mg tablet passes into breast milk.

Take Tolperisone 150 mg + Acetaminophen 325 mg tablet after food to reduce stomach discomfort. Avoid alcohol as it may increase dizziness and the risk of liver damage. 

Avoid taking Tolperisone 150 mg + Acetaminophen 325 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Tolperisone Chemical Structure: 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one

Acetaminophen: N-(4-hydroxyphenyl)acetamide 

Daily dose

Take Tolperisone 150 mg + Acetaminophen 325 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Taking excess Tolperisone 150 mg + Acetaminophen 325 mg tablet may cause severe dizziness, liver damage, nausea, vomiting, weakness, or breathing difficulty. Seek immediate medical attention if severe symptoms occur.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take Tolperisone 150 mg + Acetaminophen 325 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Tolperisone 150 mg + Acetaminophen 325 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Tolperisone 150 mg + Acetaminophen 325 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.   

What are the uses of Myotop P tablet? 

Myotop P tablet is used to relieve muscle pain, muscle stiffness, muscle spasms, back pain, neck pain, and musculoskeletal pain. 

What are the side effects of Myotop P tablet? 

Common side effects of Myotop P tablet include dizziness, nausea, drowsiness, weakness, headache, and stomach discomfort. Rarely, allergic reactions may occur. 

What is the composition of Myotop P tablet? 

Myotop P tablet contains Tolperisone 150 mg and Acetaminophen (Paracetamol) 325 mg, which help relax muscles and reduce pain. 

What are the benefits of Myotop P tablet? 

Myotop P tablet helps reduce muscle stiffness, relieves pain and spasms, improves movement, and provides comfort in muscle and joint conditions. 

1. PubChem. Tolperisone [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Feb 26]. Available from 
2. Srinivas Nalamachu, Pergolizzi JV, Kaye RE. Tolperisone for the Treatment of Acute Muscle Spasm of the Back: Results from the Dose-Ranging Phase 2 STAR Study (NCT03802565). Journal of pain research. 2020 Nov 1;Volume 13:3059–69. 
3. Tolperisone: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Drugbank.com. DrugBank; 2019. Available from 
4. Mayo Clinic. Acetaminophen (Oral route, Rectal route) [Internet]. 2024 [cited 2024 Nov 28]. Available from 
5. National Center for Biotechnology Information. Acetaminophen [Internet]. StatPearls [updated 2024 Nov 28; cited 2024 Nov 28]. Available from