Tolperisone (SR) 450 mg tablets is a muscle relaxant and used to treat muscle stiffness, muscle spasms, and pain caused by conditions affecting the muscles or spine. They help relax tight muscles and improve movement. Tolperisone (sr) 450 mg is commonly used in muscle pain, back pain, neck pain, cervical spondylosis, and muscle injuries. 

Common side effects of Tolperisone (SR) 450 mg include dizziness, weakness, nausea, stomach discomfort, headache, or low blood pressure. Rare but serious side effects may include allergic reactions such as rash, itching, swelling, or breathing difficulty. These tablets should be taken exactly as prescribed by the doctor, preferably after food. Always follow your doctor’s instructions while using Tolperisone (sr) 450 mg.         

Tolperisone (SR) 450 mg tablet is used to treat the following conditions: 

1. Muscle spasms 
2. Back pain 
3. Neck pain 
4. Muscle stiffness 
5. Cervical spondylosis 
6. Musculoskeletal pain               

More Common

1. Dizziness 
2. Weakness 
3. Headache 
4. Nausea 
5. Stomach discomfort 
6. Low blood pressure            

Less Common 

1. Allergic reactions 
2. Skin rash 
3. Breathing difficulty 
4. Swelling           

Tolperisone (sr) 450 mg tablet acts centrally on brain and spinal cord to relieve muscle stiffness/spasm without reducing strength. This helps relieve muscle stiffness, spasms, and pain, improving movement and comfort. 

Allergy / Hypersensitivity

Tolperisone (sr) 450 mg tablet may cause allergic reactions such as rash, itching, swelling, or breathing difficulty. Stop taking the medicine and consult your doctor if symptoms worsen. 

Myasthenia Gravis

If you have myasthenia gravis (a condition that causes severe muscle weakness), you should not take Tolperisone (sr) 450 mg because it can worsen muscle weakness and make symptoms more severe.

Liver Problems

If you have liver disease or a history of liver problems, inform your doctor before taking Tolperisone (sr) 450 mg because it may worsen your condition or require dose adjustment.

Kidney Problems

If you have kidney issues, tell your doctor before starting Tolperisone (sr) 450 mg because the drug may accumulate in the body and increase the risk of side effects.

Low Blood Pressure

If you already have low blood pressure, use Tolperisone (sr) 450 mg only after discussing with your doctor because it may further lower your blood pressure and cause dizziness or fainting.

Pregnancy

If you are pregnant or planning to become pregnant, inform your doctor before taking Tolperisone because its safety during pregnancy has not been fully established. 

Breastfeeding

If you are breastfeeding, inform your doctor before using Tolperisone (sr) 450 mg because it is not clearly known whether Tolperisone passes into breast milk.

Take Tolperisone (sr) 450 mg tablet after food to reduce stomach discomfort. Avoid alcohol as it may increase dizziness and the risk of liver damage. 

Avoid taking Tolperisone (sr) 450 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Tolperisone Chemical Structure: 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one 

Daily dose

Take Tolperisone (sr) 450 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended take more than 450 mg of Tolperisone per day, as exceeding the recommended dose may lead to serious side effects such as nausea, vomiting, dizziness, weakness, low blood pressure, and severe drowsiness. In rare cases, overdose may cause breathing difficulty or severe allergic reactions. Seek immediate medical attention if an overdose is suspected.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take Tolperisone (sr) 450 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Tolperisone (sr) 450 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Tolperisone (sr) 450 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.   

What are the side effects of Tolperisone (sr) 450 mg tablet? 

Tolperisone (sr) 450 mg tablet may cause side effects such as nausea, vomiting, dizziness, headache, weakness, and stomach discomfort. In rare cases, it may cause low blood pressure or allergic reactions like rash, swelling, or breathing difficulty. Seek medical help if severe symptoms occur. 

What class of drug does Tolperisone belong to? 

Tolperisone belongs to the class of centrally acting muscle relaxants. It is used to reduce muscle stiffness and spasms. 

What is the mechanism of action of Tolperisone (sr) 450 mg? 

Tolperisone (sr) 450 mg works by acting on the central nervous system. It blocks certain nerve signals in the brain and spinal cord that cause excessive muscle contraction. This helps relax tight muscles, relieve pain, and improve movement. 

What are the contraindications of Tolperisone (sr) 450 mg? 

Tolperisone (sr) 450 mg is contraindicated in patients who are allergic to tolperisone or any of its ingredients and in individuals with myasthenia gravis (a condition causing severe muscle weakness). It should also be avoided unless advised by a doctor in patients with severe liver or kidney problems. 

1. PubChem. Tolperisone [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Feb 26]. Available from 
2. Srinivas Nalamachu, Pergolizzi JV, Kaye RE. Tolperisone for the Treatment of Acute Muscle Spasm of the Back: Results from the Dose-Ranging Phase 2 STAR Study (NCT03802565). Journal of pain research. 2020 Nov 1;Volume 13:3059–69. 
3. Tolperisone: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Drugbank.com. DrugBank; 2019. Available from