Tolperisone 150 mg is an oral medicine belonging to the category of muscle relaxants and is used to treat the following conditions: 

1. Muscle spasms 
2. Cervical spondylosis 
3. Low back pain 
4. Post-stroke muscle stiffness (spasticity) 
5. Spinal cord–related muscle tightness 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

More Common

1. Nausea 
2. Vomiting 
3. Dizziness 
4. Headache 
5. Weakness or fatigue 
6. Stomach discomfort       

Less common 

1. Low blood pressure (may cause lightheadedness) 
2. Skin rash or itching 
3. Allergic reactions (swelling of face, lips, throat – rare but serious)  

Tolperisone acts on the central nervous system. It blocks certain nerve signals that cause muscles to tighten excessively. This helps muscles relax and reduces pain without causing much drowsiness compared to some other muscle relaxants. 

Allergy/Hypercreativity

 If you are allergic to Tolperisone or any ingredient in this medicine, you should avoid it because it may cause serious allergic reactions such as rash, itching, swelling of the face or throat, dizziness, or breathing difficulties. Seek medical help immediately if these occur. 

Myasthenia Gravis

If you have myasthenia gravis (a condition that causes severe muscle weakness), you should not take this medicine because it can worsen muscle weakness and make symptoms more severe.

Liver Problems

If you have liver disease or a history of liver problems, inform your doctor before taking this medicine because it may worsen your condition or require dose adjustment.

Kidney Problems

If you have kidney issues, tell your doctor before starting this medicine because the drug may accumulate in the body and increase the risk of side effects.

Low Blood Pressure

If you already have low blood pressure, use this medicine only after discussing with your doctor because it may further lower your blood pressure and cause dizziness or fainting.

Pregnancy

If you are pregnant or planning to become pregnant, inform your doctor before taking Tolperisone because its safety during pregnancy has not been fully established.  

Breastfeeding

 If you are breastfeeding, inform your doctor before using this medicine because it is not clearly known whether Tolperisone passes into breast milk.  

Avoid taking Tolperisone with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

It is usually recommended to take it after meals to reduce the chances of stomach discomfort. There are no major specific food restrictions, but alcohol should be avoided while taking this medicine because it may increase side effects such as dizziness, weakness, or low blood pressure.  

1. The medicine should be stored at room temperature.  
2. Keep away from sunlight and moisture.
3. Keep away from the reach of children. 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one 

Daily Dose

Take Tolperisone exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Do not take more than 450 mg of Tolperisone per day, as exceeding the recommended dose may lead to serious side effects such as nausea, vomiting, dizziness, weakness, low blood pressure, and severe drowsiness. In rare cases, overdose may cause breathing difficulty or severe allergic reactions. Seek immediate medical attention if an overdose is suspected. 

Tolperisone 150 mg is a centrally acting muscle relaxant used to relieve muscle spasms, stiffness, and pain associated with conditions such as lower back pain, cervical spondylosis, post-stroke spasticity, and spinal cord–related muscle tightness. It works by blocking certain nerve signals in the brain and spinal cord that cause excessive muscle contraction, thereby relaxing muscles and improving movement. Common side effects include nausea, dizziness, headache, and weakness, while serious allergic reactions are rare. It should not be used in patients allergic to tolperisone or those with myasthenia gravis, and caution is advised in individuals with liver or kidney problems.  

The usual maximum recommended dose is 450 mg per day, and taking more than this may lead to overdose symptoms such as severe dizziness, weakness, low blood pressure, vomiting, or breathing difficulty, requiring immediate medical attention.    

What are the side effects of Tolperisone? 

Tolperisone may cause side effects such as nausea, vomiting, dizziness, headache, weakness, and stomach discomfort. In rare cases, it may cause low blood pressure or allergic reactions like rash, swelling, or breathing difficulty. Seek medical help if severe symptoms occur. 

What class of drug does Tolperisone belong to? 

Tolperisone belongs to the class of centrally acting muscle relaxants. It is used to reduce muscle stiffness and spasms. 

What is the mechanism of action of Tolperisone? 

Tolperisone works by acting on the central nervous system. It blocks certain nerve signals in the brain and spinal cord that cause excessive muscle contraction. This helps relax tight muscles, relieve pain, and improve movement. 

What are the contraindications of Tolperisone? 

Tolperisone is contraindicated in patients who are allergic to tolperisone or any of its ingredients and in individuals with myasthenia gravis (a condition causing severe muscle weakness). It should also be avoided unless advised by a doctor in patients with severe liver or kidney problems. 

1. PubChem. Tolperisone [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Feb 26]. Available from 
2. Srinivas Nalamachu, Pergolizzi JV, Kaye RE. Tolperisone for the Treatment of Acute Muscle Spasm of the Back: Results from the Dose-Ranging Phase 2 STAR Study (NCT03802565). Journal of pain research. 2020 Nov 1;Volume 13:3059–69. 
3. Tolperisone: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Drugbank.com. DrugBank; 2019. Available from