Acetaminophen 125 mg + Chlorpheniramine 2.5 mg + Phenylephrine 1 mg/5 mL syrup is a combination oral liquid used to relieve symptoms of upper respiratory infections, such as fever, headache, body aches, runny nose, sneezing, and nasal congestion. 

It contains acetaminophen, which helps reduce fever and relieve mild pain; chlorpheniramine, an antihistamine that helps reduce allergy symptoms such as sneezing and a runny nose; and phenylephrine, a decongestant that helps reduce swelling inside the nose and relieve nasal congestion. 

This medicine should be given only as directed by your doctor or pharmacist, especially in children. Do not give more than the recommended dose. 

Some people may experience drowsiness, dry mouth, nausea, stomach discomfort, or dizziness while taking this medicine.  

Acetaminophen 125 mg + Chlorpheniramine 2.5 mg + Phenylephrine 1 mg / 5 ml is used relieve: 

1. Fever  
2. Mild to moderate pain 
3. Cold and its symptoms such as sneezing, runny nose, and nasal congestion.      

More Common

1. Drowsiness 
2. Dry mouth 
3. Nausea 
4. Dizziness 
5. Stomach discomfort                   

Less Common 

1. Vomiting 
2. Headache 
3. Difficulty sleeping 
4. Increased heart rate 
5. Restlessness 
6. Skin rash                   

This medicine contains three medicines that work in different ways. 

Acetaminophen blocks the production of chemicals called prostaglandins, which are involved in pain and fever. This helps reduce fever and relieve mild pain. Chlorpheniramine blocks histamine, a chemical released during an allergic reaction. This helps reduce sneezing, runny nose, and other allergy symptoms. Phenylephrine narrows swollen blood vessels inside the nose. This reduces swelling and helps open the blocked nose. 

Together, these medicines help relieve fever, mild pain, runny nose, sneezing, and nasal congestion associated with cold or allergy symptoms.    

Allergies

If you are allergic to acetaminophen, chlorpheniramine, phenylephrine, or any ingredient in this medicine, inform your doctor before taking it, as it may cause an allergic reaction such as skin rash, swelling, or difficulty breathing.

Other acetaminophen medicines

If you are already taking another medicine containing acetaminophen or paracetamol, inform your doctor or pharmacist before taking this medicine, as taking too much can cause serious liver damage.

High blood pressure

If you have high blood pressure, tell your doctor before taking this medicine, as phenylephrine may increase blood pressure.

Heart problems

If you have heart disease or an abnormal heart rhythm, inform your doctor before taking this medicine, as phenylephrine may affect heart rate or blood pressure.

Thyroid problems

If you have an overactive thyroid, tell your doctor before taking this medicine, as phenylephrine may worsen some symptoms.

Drowsiness

If this medicine makes you sleepy or dizzy, avoid driving or operating machinery, as chlorpheniramine may reduce alertness.

Children

If this medicine is being given to a child, use only the dose recommended by the doctor, as an incorrect dose may cause serious side effects.

Pregnancy

If you are pregnant or planning to become pregnant, inform your doctor before taking this medicine, so your doctor can decide whether it is suitable for you.

Breastfeeding

If you are breastfeeding, tell your doctor before taking this medicine, as some of its ingredients may pass into breast milk.

This medicine can be taken before or after food. Take it with water as directed by your doctor. Avoid alcohol while taking this medicine, as it may increase drowsiness or dizziness.

Avoid taking Acetaminophen 125 mg + Chlorpheniramine 2.5 mg + Phenylephrine 1 mg / 5 ml with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Acetaminophen: N-(4-hydroxyphenyl)acetamide 

Chlorpheniramine: 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine 

Phenylephrine: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol 

Daily dose

Take Acetaminophen 125 mg + Chlorpheniramine 2.5 mg + Phenylephrine 1 mg / 5 ml exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Taking more than the prescribed amount may cause excessive drowsiness, restlessness, stomach pain, thirst, headache, vomiting, or diarrhea. If you accidentally take more than the prescribed dose, seek medical attention promptly.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.        

What are the uses of acetaminophen, chlorpheniramine, and phenylephrine syrup? 

Acetaminophen, chlorpheniramine, and phenylephrine syrup is used to relieve symptoms of cold and upper respiratory infections, such as fever, mild headache and body aches, sneezing, runny nose, and a blocked or stuffy nose. Acetaminophen helps reduce fever and pain, chlorpheniramine helps control allergy symptoms, and phenylephrine helps relieve nasal congestion. 

Can children take acetaminophen, chlorpheniramine, and phenylephrine syrup? 

Yes, children may be given this medicine when prescribed by a doctor. The dose should be based on the child’s age and weight, giving more than recommended amounts may cause serious side effects. 

What are the common side effects of acetaminophen, chlorpheniramine, and phenylephrine syrup? 

Common side effects of acetaminophen, chlorpheniramine, and phenylephrine syrup include drowsiness, dry mouth, nausea, stomach discomfort, dizziness, headache, or restlessness. These effects are usually mild but consult your doctor if they persist or become troublesome. 

Can this syrup be taken for a blocked nose? 

Yes, medicine in phenylephrine helps unclog blocked nose by reducing swelling around the nose, which can make breathing easier and relieve a blocked or stuffy nose. Consult with your doctor before using it, especially if you have high blood pressure or heart problems. 

1. PubChem. Phenylephrine [Internet]. Nih.gov. PubChem; 2019 [cited 2026 Sept 21]. Available from 
2. National Center for Biotechnology Information. Acetaminophen [Internet]. National Library of Medicine. PubChem; 2019 [cited 2026 Sept 21]. Available from 
3. PubChem. Chlorpheniramine [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 21]. Available from