Clindamycin 1% + Nicotinamide 4% Gel is a topical medicine used to treat acne (pimples and spots). It helps reduce acne-causing bacteria and inflammation, which can help control pimples, redness, and swelling. 

It contains clindamycin, an antibiotic that helps reduce acne-causing bacteria, and nicotinamide, a form of vitamin B3 that helps reduce skin inflammation and irritation. 

Some people may experience mild and temporary dryness, redness, burning, itching, or skin irritation after application.

This gel is mainly used to treat acne and reduce redness, swelling, and inflammation associated with acne. 

More Common

1. Dryness  
2. Redness  
3. Burning or stinging  
4. Itching  
5. Skin irritation  
6. Peeling                

Less Common 

1. Increased skin sensitivity  
2. Skin rash  
3. Worsening irritation  
4. Swelling  
5. Severe or persistent skin dryness  
6. Signs of an allergic reaction                

This gel contains two medicines that work differently. Clindamycin is an antibiotic that helps reduce the growth of bacteria associated with acne. Nicotinamide is a form of vitamin B3 that has anti-inflammatory properties and helps reduce redness and inflammation in the skin. Together, they help control acne and reduce associated inflammation.

Allergy or Hypersensitivity

If you are allergic to clindamycin, lincomycin, nicotinamide, or any ingredient in the gel, tell your doctor before using it.

Open or damaged skin

Do not apply the gel to open wounds, cuts, or severely irritated skin unless advised by your doctor.

Eyes and sensitive areas

Avoid contact with the eyes, mouth, nose, and other sensitive areas. If the gel accidentally gets into your eyes, rinse thoroughly with clean water.

Antibiotic use

Use this medicine only for the duration prescribed by your doctor. Unnecessary or prolonged use of topical antibiotics may contribute to antibiotic resistance.

Pregnancy

If you are pregnant or planning to become pregnant, tell your doctor before using this gel. Use it only when recommended.

Breastfeeding

If you are breastfeeding, speak with your doctor before using the gel. Avoid applying it to the breast or nipple area unless specifically advised.

As this medicine is applied to the skin, significant food interactions are not expected when it is used as directed.

Avoid taking Clindamycin 1% + Nicotinamide 4% Gel with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Clindamycin: (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide 

Nicotinamide: pyridine-3-carboxamide 

Daily dose

Take Clindamycin 1% + Nicotinamide 4% Gel exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

 If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Using too much of the cream may increase burning, irritation, or other local side effects. If you accidentally swallow a large amount or develop severe symptoms after excessive use, seek medical attention promptly.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Gently spread the gel over the acne-prone skin.  
2. Wash your hands after applying it.  
3. Avoid contact with the eyes, mouth, and other sensitive areas.  
4. Do not apply more gel than recommended. Using extra gel will not clear acne faster and may increase skin irritation.      

What are the benefits of using Clindamycin 1% + Nicotinamide 4% Gel for acne treatment? 

It helps reduce acne-causing bacteria and skin inflammation, which can help control pimples, redness, and swelling. Clindamycin works against acne-associated bacteria, while nicotinamide helps calm skin inflammation. 

What are the potential side effects of Clindamycin 1% + Nicotinamide 4% Gel? 

Common side effects of clindamycin and nicotinamide may include dryness, redness, burning, stinging, itching, peeling, or skin irritation at the application site. If you develop severe irritation, swelling, or persistent diarrhoea, contact your doctor. 

How long does it take for this acne gel to show results? 

You may start noticing improvement in acne within a few weeks of regular use. The full benefit may take several weeks to a few months, depending on your acne and response to treatment. Continue using it as prescribed and speak with your doctor if your acne does not improve. 

How to apply Clindamycin 1% + Nicotinamide Gel? 

Clean and gently dry the affected area, then apply a thin layer of the gel as directed by your doctor. Gently spread it over the acne-prone area and wash your hands afterward. Avoid contact with the eyes, mouth, and other sensitive areas. 

Where can I buy Clindamycin 1% + Nicotinamide 4% Gel online in India? 

You can buy Clindamycin 1% + Nicotinamide 4% Gel online from SayaCare. To verify that the medicine is authentic SayaCare provides medicine’s quality report to the customers  

Reference  

1. PubChem. Clindamycin [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 18]. Available from 
2. PubChem. Nicotinamide [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 18]. Available from 
3. Steris Healthcare Pvt Ltd. Clindamycin and Nicotinamide Gel for Acne – Benefits, Uses & Side Effects | Steris Healthcare Pvt Ltd – Mumbai [Internet]. Steris Healthcare Pvt Ltd. 2026 [cited 2026 Sept 18]. Available from