Pregabalin with methylcobalamin is commonly used to treat nerve pain from diabetes, sciatica (leg -related nerve pain), or herpes infection. Pregabalin calms nerve signals, while methylcobalamin (vitamin B12) helps repair damaged nerves. It’s taken once or twice daily, and common side effects include sleepiness, dizziness, blurred vision, dry mouth, weight gain, and swelling in hands or feet. Alcohol should be avoided, and activities needing focus, like driving, may be unsafe. It’s not suitable for children, pregnant or breastfeeding women, or people with kidney or heart issues. Sudden stoppage may cause mood changes, so always follow your doctor’s advice.  

Pregabalin 75 mg (SR) and methylcobalamin 750 mcg are oral combination medicines belonging to the categories of anticonvulsants and vitamin supplements, respectively. It is used to treat following conditions: 

1. Nerve pain due to herpes infection 
2. Nerve pain due to diabetics 
3. Seizures 
4. Musculoskeletal pain (Fibromyalgia) 
5. Nerve pain due to Sciatica (leg related nerve pain) 

More Common

1. Dizziness  
2. Sleepiness  
3. Headache  
4. Tiredness  
5. Fluid retention  
6. Nausea  
7. Blurred vision  
8. Dry mouth  
9. Weight gain 

Less Common

1. Breathing problems or wheezing 
2. Racing heart 
3. Fever or general ill feeling 
4. Swollen lymph nodes 
5. Swelling of the face, lips, mouth, tongue, or throat 
6. Trouble swallowing or throat tightness 
7. Itching, skin rash, or pale red bumps on the skin called hives 
8. Nausea or vomiting 
9. Dizziness, feeling lightheaded, or fainting 
10. Stomach cramps 
11. Joint pain 
12. Suicidal thoughts 
13. Hallucinations 
14. Dizziness or confusion 
15. Blurry vision 
16. Slurred speech 
17. Sweating 
18. Feeling shakiness 

Pregabalin and methylcobalamin work by teaming up like a firefighter and a repair technician for your nerves. Pregabalin rushes in to calm the overactive “alarm signals” that nerves send during pain especially in conditions like diabetic neuropathy, sciatica, or postherpetic neuralgia. Meanwhile, methylcobalamin (a powerful form of vitamin B12) steps in to nourish and repair the damaged nerve fibers, helping them heal and function better over time. Together, they not only silence the noise of nerve pain but also help rebuild the wiring underneath. 

Pregnancy

Pregabalin and methylcobalamin haven’t shown direct effects on fetus in human studies, but animal studies suggest pregabalin may affect development, so always consult your doctor before use.

Breastfeeding

Pregabalin and methylcobalamin pass into breast milk and can cause toxicity, so tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop it.

Kidney and Liver Problems

Pregabalin and methylcobalamin are generally safe in patients with liver and kidney disease, but caution is advised. Rarely, pregabalin may cause serious liver injury or worsen kidney function. If you have significant liver or kidney problems, consult a doctor before using them.

Past Mental Health Issues

Pregabalin directly acts on the brain and causes side effects like sedation, drowsiness, and suicidal thoughts. Inform the doctor about your past mental health issues before using it.

Pregabalin and methylcobalamin combination are generally safe to consume along with food, but it is recommended to avoid consuming alcohol and smoking at the same time while taking this medicine, as it may affect the blood glucose levels and can also cause drowsiness and sedation, as they directly act on the brain. 

Avoid taking pregabalin 75 and methylcobalamine 750 mcg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Pregabalin- (3S) -3-(aminomethyl)-5-methylhexanoic acid 

Methyl Cobalamine- Coα-[α-(5,6-dimethylbenzimidazolyl)]-Coβ-methylcobamide

Daily Dose

Take pregabalin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Do not take more than 600 mg of pregabalin and 2.5 mg of methylcobalamine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and provide the patient with sufficient care. 

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

1. If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.  
2. This pregabalin + methylcobalamin should be taken after meals or as advised by your doctor.  
3. Follow your doctor’s instructions on the dosage and timing of this medication.  
4. Swallow pregabalin + methylcobalamin with a glass of water. Do not crush, break, or chew it. 

What are pregabalin + methylcobalamin uses? 

Pregabalin with methylcobalamin is commonly used to treat nerve pain from diabetes, sciatica, or herpes and seizures.  

What are the pregabalin + methylcobalamin side effects? 

Some common side effects of pregabalin and methylcobalamin include feeling sleepy or dizzy, blurred vision, dry mouth, weight gain, or swelling in hands and feet. 

What is the maximum pregabalin methylcobalamin dosage per day? 

It is not recommended to take more than 600 mg of pregabalin and methylcobalamine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and provide the patient sufficient care.

What are pregabalin+ methylcobalamin brand name in India? 

Pregabalin + Methylcobalamin is sold under many brand names like Pregmax-M, Neuracalm-75, and Pregaba MNT. While the core ingredient is the same, not all brands meet safety standards set by India’s CDSCO. Saya Care ensures patients receive safe, effective treatment by providing the medication along with a verified quality test report, offering transparency and assurance.

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