Pyridoxine HCl 10 mg + Doxylamine 10 mg + Folic Acid 2.5 mg tablet is a combination medicine commonly used to help manage nausea and vomiting during pregnancy. Doxylamine is an antihistamine that helps reduce signals in the body that can trigger nausea and vomiting, while pyridoxine (vitamin B6) supports normal nerve function and helps manage nausea. Folic acid supports the healthy development of the baby’s brain and spinal cord during pregnancy. 

This medicine should be taken only as prescribed by your doctor, and the dose and duration depend on your symptoms and pregnancy needs. 

Pyridoxine HCl 10 mg + Doxylamine 10 mg + Folic Acid 2.5 mg is used to manage nausea and vomiting during pregnancy. 

More Common

1. Drowsiness 
2. Dizziness 
3. Headache 
4. Dry mouth 
5. Tiredness 
6. Constipation             

Less Common 

1. Severe or persistent dizziness 
2. Extreme drowsiness 
3. Difficulty passing urine 
4. Blurred vision 
5. Confusion 
6. Allergic reactions such as skin rash, swelling, or difficulty breathing           

This medicine contains doxylamine, pyridoxine, and folic acid. Doxylamine is an antihistamine that helps reduce signals in the body that can trigger nausea and vomiting. Pyridoxine, also known as Vitamin B6, supports normal nerve function and is used to help manage nausea during pregnancy. Folic acid is a synthetic form of vitamin B9 that supports normal cell growth and helps prevent certain birth defects affecting the baby’s brain and spinal cord. 

Allergy or Hypersensitivity

If you are allergic to doxylamine, pyridoxine, folic acid, or any ingredient in this medicine, it may cause a rash, swelling, or breathing difficulty. Tell your doctor about any known allergies before taking it.

Glaucoma

If you have glaucoma or increased pressure in the eyes, tell your doctor before taking this medicine, as doxylamine may worsen the condition.

Asthma or breathing problems

If you have asthma or other breathing problems, tell your doctor before taking this medicine, as doxylamine may worsen breathing difficulties.

Liver problems

If you have liver disease, tell your doctor before taking this medicine. You may require medical monitoring.

Urinary problems

If you have difficulty passing urine or a condition affecting the urinary tract, tell your doctor before taking this medicine.

Pregnancy

This medicine is commonly used to manage nausea and vomiting during pregnancy, but it should be taken only as prescribed by your doctor.

Breastfeeding

Tell your doctor if you are breastfeeding before taking this medicine, as doxylamine may cause drowsiness and may affect the breastfed infant.

Avoid alcohol while taking this medicine, as it may increase drowsiness and dizziness. Take the medicine before or after food as directed by your doctor. If the medicine causes stomach discomfort, follow your doctor’s advice regarding when to take it with food. 

Avoid taking Pyridoxine hcl 10 mg + Doxylamine 10 mg + Folic Acid 2.5 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Pyridoxine: 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride

Doxylamine: N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine 

Folic Acid: (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6 yl)methylamino]benzoyl]amino]pentanedioic acid 

Daily dose

Take Pyridoxine hcl 10 mg + Doxylamine 10 mg + Folic Acid 2.5 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

 Taking more than the prescribed amount may cause severe drowsiness, dizziness, confusion, dry mouth, or other side effects. If you suspect an overdose, seek immediate medical attention.

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.    

What are the benefits of supplements containing Pyridoxine, Doxylamine, and Folic Acid? 

The combination helps manage nausea and vomiting during pregnancy while providing folic acid, which supports normal cell growth and development of the baby’s brain and spinal cord. Pyridoxine also supports normal nerve function. 

What are the primary uses of a medication combining Pyridoxine, Doxylamine, and Folic Acid? 

This combination is primarily used to manage nausea and vomiting during pregnancy. Doxylamine and pyridoxine help relieve nausea and vomiting, while folic acid supports normal fetal development.

Where can I buy tablets combining Pyridoxine, Doxylamine, and Folic Acid online? 

You can order Pyridoxine HCl 10 mg + Doxylamine 10 mg + Folic Acid 2.5 mg tablets online in India through SayaCare. Keep a valid prescription ready when ordering, as this combination should be taken under medical supervision.

What alternatives exist for Pyridoxine, Doxylamine, and Folic Acid supplements for nausea relief? 

Alternatives for nausea and vomiting during pregnancy may include dietary changes, small frequent meals, ginger, or other medicines prescribed by a doctor. The most suitable option depends on the severity of symptoms and your pregnancy. Do not start any medicine or supplements without medical advice.

Is a prescription required for products with Pyridoxine and Doxylamine in India? 

Yes, products containing doxylamine and pyridoxine should be taken under medical supervision. Doxylamine is a prescription medicine in India, so you may need a valid prescription to buy products containing it. 

How do I use supplements with Pyridoxine, Doxylamine, and Folic Acid for morning sickness? 

Take Pyridoxine, Doxylamine, and Folic Acid exactly as prescribed by your doctor. Do not change the dose or frequency on your own. Doxylamine may cause drowsiness, so avoid driving or operating machinery if you feel sleepy.

Are there any side effects of taking Pyridoxine, Doxylamine, and Folic Acid together? 

Yes, common side effects of pyridoxine, doxylamine and folic acid may include drowsiness, dizziness, headache, dry mouth, tiredness, and constipation. Doxylamine is mainly responsible for drowsiness. Seek medical attention if you develop severe dizziness, difficulty breathing, swelling, or other serious symptoms. 

Reference  

1. PubChem. Pyridoxine Hydrochloride [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Sept 2]. Available from 
2. PubChem. Doxylamine [Internet]. Nih.gov. PubChem; 2025 [cited 2026 Sept 2]. Available from 
3. PubChem. Folic Acid [Internet]. pubchem.ncbi.nlm.nih.gov. [cited 2026 Sept 2]. Available from 
4. Doxylamine and pyridoxine (oral route) [Internet]. Mayo Clinic. 2024 [cited 2026 Sept 2]. Available from